|Worm gene name:||pdr-1|
|Worm sequence name:||K08E3.7|
|Related human gene:||PARK2|
|Associated human disease:||Early-Onset Parkinson's Disease|
|People involved in this project:||
|Left primer sequence:||tgtacctcgtgtggaatgga|
|Right primer sequence:||caatgtaacttcagacacaccg|
|Size of PCR product:||172|
|Brief description:|| Although there are multiple genes in humans that cause Parkinson's symptoms, the PARK2 gene (also known as parkin gene) is responsible for causing the Early-Onset Parkinson's symptoms (onset < 40 years old). Common symptoms between Early-Onset Parkinson's and Classical include bradykinesia, rigidity, and tremor. However, the two are otherwise quite different. Early-Onset can begin as early as in childhood, with symptoms such as a difficulty in walking far distances. A deletion of the PARK2 gene causes Early-Onset Parkinson's.
When comparing the human PARK2 gene to the C. elegans pdr-1 gene, there are 128/456 (28%) identities, 190/456 (41%) positives, and 91/456 (19%) gaps. PARK2's amino acid sequence is: "MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCD LDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLA VILHTDSRKDSPPAGSPAGRSIYNSFYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQGP SCWDDVLIPNRMSGECQSPHCPGTSAEFFFKCGAHPTSDKETSVALHLIATNSRNITCIT CTDVRSPVLVFQCNSRHVICLDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKE LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGC GFAFCRECKEAYHEGECSAVFEASGTTTQAYRVDERAAEQARWEAASKETIKKTTKPCPR CHVPVEKNGGCMHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV"
|Report any problems that might have appeared and any solutions:||None currently known|